College football fans will be treated to several mouthwatering matchups as part of the Week 1 college football schedule. Saturday’s slate kicks off with a potential championship preview when the No. 1 Texas Longhorns travel to take on the No. 3 Ohio State Buckeyes at noon ET. Other notable matchups on Saturday include No. 8 Alabama vs. Florida State at 3:30 p.m. and No. 9 LSU vs. No. 4 Clemson at 7:30. Clemson is favored by four points at home, according to the latest Week 1 college football odds at bet365, but SportsLine’s model is backing LSU to cover the spread in well over 60% of simulations.
The model is also backing Alabama to cover against Florida State, while the Under (47.5) hits in nearly 60% of simulations in Texas vs. Ohio State. Before locking in your Week 1 college football picks on your favorite betting sites like bet365, be sure to check out the top college football betting picks from SportsLine’s proven computer model. Claim the latest bet365 bonus code here, where new users get $200 in bonus bets, or get up to a $1,000 first bet safety net:
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anybody following its college football betting picks on betting sites could have seen strong returns.
Best Week 1 college football picks:
- Under 47.5 points in Texas vs. Ohio State
- Alabama (-13.5) vs. Florida State
- LSU (+4) vs. Clemson
Combining the model’s three picks into a Week 1 college football parlay at DraftKings would result in a payout of +605 (risk $100 to win $605). You can also get $200 in bonus bets instantly and over $200 off NFL Sunday Ticket with the latest DraftKings promo code:
Under 47.5 points in Texas vs. Ohio State
Both of these teams featured dominant defenses in 2024, and they’re expected to be full of playmakers again in 2025. Ohio State featured the top-ranked scoring defense last season, while Texas finished the year ranked third. Both teams will also be breaking in new starting quarterbacks, which could lead to sputtering offensive performances in an early-season showdown. The model has also taken into account that the Under has hit in three of the last four meetings between these powerhouses. SportsLine’s model is projecting 45 combined points on Saturday, helping the Under hit in well over 50% of simulations.
Alabama (-13.5) vs. Florida State
The Crimson Tide enter the 2025 season full of confidence after naming Ty Simpson the starting quarterback ahead of their Week 1 matchup against FSU. Simpson will be throwing to one of the nation’s best receivers in Ryan Williams, who hauled in 48 receptions for 865 yards and eight touchdowns in his freshman campaign. Meanwhile, Florida State continues its rebuild and will feature eight incoming transfers as starters on the offensive side of the ball. In addition, Alabama is 9-0 against the spread in its last nine games played in Week 1, while Florida State is 1-8 ATS in its past nine games played in August. SportsLine’s model is backing Alabama to cover the spread in nearly 60% of simulations, identifying the Crimson Tide as one of its Week 1 college football best bets.
LSU (+4) vs. Clemson
LSU brings back one of the nation’s top-ranked quarterbacks in Garrett Nussmeier. The senior signal caller threw for 4,052 yards and 29 touchdowns last season, and he’ll look to put together another strong campaign for Brian Kelly’s offense. Meanwhile, Dabo Swinney’s squad has struggled against SEC opponents in recent years, posting a 1-6 against the spread record in its last seven games against an SEC opponent. SportsLine’s model is projecting LSU goes on the road and covers the spread in well over 60% of simulations.
Want more Week 1 college football picks?
You’ve seen the model’s Week 1 college football best bets. Now, get against the spread, total and money-line picks for every Week 1 CFB game here, all from the model that’s simulated every game 10,000 times.
Also at SportsLine:
You can also see Week 1 college football picks from insider Thomas Casale. Visit SportsLine to see his best bets. SportsLine’s Micah Roberts, who is 9-2 in his last 11 spread picks involving Ohio State, has locked in his best bets for Ohio State vs. Texas right here.